Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Isopropyl myristate is used as a topical treatment for scabies, primarily as an ingredient in certain scabicidal formulations. The scientific rationale for its use is based on its ability to act as a solvent that disrupts the exoskeleton of the mite, leading to dehydration and death. Several studies, including clinical trials, have evaluated isopropyl myristate-based products—most notably a 50% solution in a cyclomethicone vehicle. These products have demonstrated some efficacy in treating scabies infestations, especially when compared to placebo, though results are generally considered modest and less robust than traditional first-line agents like permethrin or oral ivermectin.

For example, a randomized controlled trial published in the British Journal of Dermatology (2002) found that a single application of a 50% isopropyl myristate solution achieved cure rates similar to established therapies in some patient groups, though recurrence was somewhat higher. The compound is also valued for its low toxicity and minimal skin irritation, making it a suitable alternative in cases of sensitivity to standard treatments. However, the overall body of evidence remains limited, and isopropyl myristate is not universally recommended as a first-line therapy in clinical guidelines.

Therefore, while there is some scientific validation for its use against scabies, the evidence base is moderate at best, and further large-scale studies would be necessary to fully establish its efficacy and comparative effectiveness.

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Products containing Isopropylmyristate