Evidence supporting the use of: Quercetin
For the health condition: Rhinitis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Quercetin is a naturally occurring flavonoid found in many fruits and vegetables and has been studied for its potential effects on allergic rhinitis. The scientific rationale for its use is based on its anti-inflammatory and antioxidant properties. Quercetin is thought to stabilize mast cells, which are involved in the release of histamine and other mediators responsible for allergy symptoms such as sneezing, runny nose, and nasal congestion. Several in vitro and animal studies have shown that quercetin can inhibit histamine release and reduce the expression of pro-inflammatory cytokines.

Some small human clinical trials and open-label studies have suggested that quercetin supplementation may help reduce symptoms of allergic rhinitis, particularly when combined with other compounds like vitamin C or bromelain. However, these studies often have methodological limitations, such as small sample sizes, lack of blinding, or use of combination products rather than quercetin alone, making it difficult to draw firm conclusions about its efficacy.

Systematic reviews and guidelines have generally concluded that, while there is a plausible mechanism and some preliminary evidence, robust clinical data supporting the effectiveness of quercetin for rhinitis are lacking. More well-designed, placebo-controlled trials are needed. Thus, while the use of quercetin for rhinitis is supported by scientific theory and some early evidence, the overall quality and quantity of clinical evidence is low, justifying a moderate-low rating.

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