Evidence supporting the use of: Quercetin
For the health condition: Rhinitis, Allergic

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Quercetin is a flavonoid found in many fruits, vegetables, and grains, and it has been investigated for its potential role in supporting or treating allergic rhinitis. The rationale for its use is primarily based on its anti-inflammatory and antioxidant properties, as well as its ability to modulate immune responses. Quercetin has been shown in several in vitro and animal studies to inhibit the release of histamine and other inflammatory mediators from mast cells and basophils, which are key players in the allergic response that leads to rhinitis symptoms.

Some small clinical studies and pilot trials in humans have reported beneficial effects of quercetin supplementation on symptoms of allergic rhinitis, such as nasal congestion, sneezing, and itching. For example, a few randomized controlled trials have indicated that quercetin may reduce symptom severity and improve quality of life in patients with seasonal allergies, likely due to its mast cell-stabilizing effects and inhibition of inflammatory cytokines. However, the number of high-quality human studies remains limited, and results are not entirely consistent across trials.

Despite promising preclinical evidence and some supportive clinical data, the overall strength of evidence is moderate at best, with a need for larger, well-designed randomized controlled trials to confirm efficacy and determine optimal dosing. As such, quercetin is sometimes used as an adjunctive, natural approach for allergic rhinitis, but it should not replace standard therapies. Individuals should consult healthcare professionals before starting supplementation, especially if they are on other medications.

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