Evidence supporting the use of: Lactobacillus casei
For the health condition: Rhinitis, Allergic

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactobacillus casei, a probiotic bacterium, has some scientific evidence supporting its use in allergic rhinitis, though the evidence is still emerging and not definitive. Several clinical studies and systematic reviews have investigated the role of probiotics in modulating immune responses associated with allergic diseases, including allergic rhinitis. The underlying rationale is that probiotics like L. casei can influence the gut microbiota and, through the gut-immune axis, help regulate immune responses that are implicated in allergies.

A number of randomized controlled trials (RCTs) have examined the effect of L. casei supplementation on symptoms of allergic rhinitis. For example, some studies have reported that participants who consumed L. casei experienced improvements in nasal symptom scores and quality of life compared to placebo. The proposed mechanisms include enhanced production of regulatory T cells, modulation of Th1/Th2 balance, and reduced inflammatory cytokines.

However, results across studies are mixed. Some trials have found only modest or no benefit, and systematic reviews highlight inconsistencies in study design, probiotic strains, dosages, and patient populations. Overall, while there is scientific plausibility and some supportive clinical data, the strength of evidence is moderate at best (rated 2/5), and L. casei cannot yet be considered a definitive or primary therapy for allergic rhinitis. More large, well-conducted RCTs are needed to clarify its role.

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