Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Taxillus chinensis (commonly known as Chinese mistletoe, “Sang Ji Sheng” in Traditional Chinese Medicine) has a long-standing history of use in East Asian herbal medicine for musculoskeletal disorders, including rheumatoid arthritis (RA). In traditional practice, it is believed to “strengthen bones and tendons,” “expel wind-dampness,” and “alleviate pain,” which are concepts in TCM associated with joint diseases like RA. Ancient texts, such as the “Shennong Bencao Jing,” reference its use for conditions characterized by joint pain and weakness.

Modern scientific evidence is limited. Some pharmacological studies have identified anti-inflammatory and immunomodulatory properties in extracts of Taxillus chinensis, such as the inhibition of pro-inflammatory cytokines (e.g., TNF-α, IL-6) in cell and animal models. However, rigorous clinical trials in patients with RA are lacking, and there is insufficient high-quality evidence to definitively support its efficacy or safety for this indication. Therefore, its primary use in RA is based on traditional knowledge, with only preliminary scientific investigation. The overall evidence rating is 2, reflecting traditional support and limited preclinical data, but a lack of robust clinical validation.

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