Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Tanshinone, a compound derived from the traditional Chinese medicinal herb Salvia miltiorrhiza (Danshen), has attracted attention for its potential effects on rheumatoid arthritis (RA). The use of Salvia miltiorrhiza in rheumatic diseases is rooted in traditional Chinese medicine, but more recently, Tanshinone—especially Tanshinone IIA—has been studied in preclinical models for its anti-inflammatory and immunomodulatory properties relevant to RA. Experimental studies in vitro and in animal models have shown that Tanshinone IIA can inhibit the production of pro-inflammatory cytokines (such as TNF-α, IL-1β, and IL-6), suppress synovial fibroblast proliferation, and reduce oxidative stress, all of which are implicated in the pathogenesis of RA. Some studies also suggest it may modulate signaling pathways like NF-κB and MAPK, further contributing to its anti-arthritic effects.

However, clinical evidence supporting the use of Tanshinone in human RA patients is limited. Most of the current data derive from laboratory and animal studies, with few well-controlled human trials published to date. Thus, while there is a scientific rationale and preliminary evidence for its use, the strength of evidence remains modest and primarily preclinical. Systematic reviews have noted the need for more robust clinical trials to establish efficacy and safety in humans. Therefore, the evidence rating is 2 out of 5, reflecting promising but not yet clinically validated support.

More about Tanshinone
More about Rheumatoid Arthritis

Other ingredients used for Rheumatoid Arthritis

Other health conditions supported by Tanshinone

Products containing Tanshinone