Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Sterones is a broad term often used to refer to corticosteroids (such as prednisone, prednisolone, and methylprednisolone), which are well-established medications in the management of rheumatoid arthritis (RA). The use of corticosteroids in RA is strongly supported by extensive scientific research and clinical experience. Corticosteroids act as potent anti-inflammatory and immunosuppressive agents, rapidly reducing joint inflammation, pain, and swelling in patients with active RA. Numerous randomized controlled trials and meta-analyses have demonstrated their efficacy in controlling disease flares and improving quality of life, particularly as a bridging therapy while slower-acting disease-modifying antirheumatic drugs (DMARDs) take effect.

Guidelines from major rheumatology organizations, such as the American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR), recommend corticosteroids for short-term use in RA to control symptoms and limit joint damage. However, long-term use is generally discouraged due to the risk of adverse effects, including osteoporosis, infections, hypertension, and metabolic disturbances. In summary, the use of corticosteroids ("sterones") in RA is justified by robust scientific evidence, and they play an important adjunctive role in RA therapy when used judiciously.

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