Evidence supporting the use of: Salicin
For the health condition: Rheumatoid Arthritis

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Salicin, a natural compound found in willow bark, has a long history of use in traditional medicine for treating pain and inflammation, including symptoms associated with rheumatoid arthritis (RA). Its use dates back to ancient civilizations such as the Egyptians, Greeks, and indigenous peoples, who employed willow bark preparations for various ailments involving pain and swelling. The traditional use is rooted in observations that willow bark tea or extracts could alleviate joint discomfort, fever, and other inflammatory symptoms.

Modern research has identified salicin as the active ingredient responsible for willow bark's therapeutic effects. Salicin is metabolized in the body to salicylic acid, which has anti-inflammatory and analgesic properties similar to aspirin (acetylsalicylic acid). However, while these mechanisms parallel those of nonsteroidal anti-inflammatory drugs (NSAIDs), which are standard in RA treatment, robust clinical evidence directly supporting salicin or willow bark for RA is limited. Most studies have focused on osteoarthritis or general pain rather than specifically on RA.

In summary, the use of salicin for rheumatoid arthritis is primarily justified by traditional use, with some scientific plausibility based on its mechanism of action. Nonetheless, high-quality clinical trials in RA patients are lacking, so the overall evidence rating is modest.

More about Salicin
More about Rheumatoid Arthritis

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adrenal cortex
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algal oil
alpha-linolenic acid (ALA)
alpha-pinene
anthocyanins
ashwagandha
astaxanthin
borage oil
celery
coenzyme Q10 (CoQ10)
turmeric
curcumin
d-alpha tocopherol
DHA (docosahexaenoic acid)
diallyl disulfide (DADS)
dong quai root
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
evening primrose oil
fisetin
fish protein
gamma linolenic acid (GLA)
gamma tocopherol
genistein
ginger
green-lipped mussel
krill oil
luteolin
Methylsulfonylmethane (MSM)
Myristoleate
omega-3 fatty acids
phospholipids
resveratrol
rose hips
slippery elm bark
sulforaphane glucosinolate
Urolithin A
vitamin B6
vitamin C
vitamin D
vitamin D3
Watercress
white willow
alpinia galangal
smilax
Fumaria parviflora
Szechuan lovage
amber
teasel
guelder rose
Gentiana macrophylla
Abies spectabilis
AMP-activated protein kinase (AMPK)
clematis
15,16-Dihydrotanshinone I
Aralia
Akebia
antler
apigenin
Abrus
andrographolide
amentoflavone
alpha-lipoic acid
anthocyanidins
ampelopsin
Actaea spicata
arjunic acid
apocynin
arctiin
astragalin
Boswellic Acid
baicalein
bogbean
Boswellia
Black willow
barbasco
bovine cartilage / glycosaminoglycan
baicalin
Black Hellebore
bee venom
Bergenia
cod liver oil
cortisol
Clerodendrum phlomidis
cyanidin
Chinese fleeceflower
Chinese pond turtle
chuchuhuasi
Cetylated Fatty Acids
C-phycocyanin
cannabidiol
carnosic acid
docosahexaenoic Acid
Dihomo-gamma-linolenic acid
Eicosatetraenoic acid
eicosapentaenoic acid
evening primrose oil
fat liver oil
fructoborate
Flemingia philippinensis
frankincense
flavanols
flavones
ginkgetin
Gypenoside
horse gram
Hyperoside
Hellebore
hydroxytyrosol
Harpagoside
Jatropha macrantha
Kaempferol
mangiferin
Myricetin
madder
Marine fat
Nobiletin
Osthole
Puerarin
Piper chaba
Phaeophyceae
proteoglycans
Polydatin
polyunsaturated fat
Palmitoylethanolamide (PEA)
Qin Jiao
Silkmoth
Schizochytrium Oil
Schizochytrium
Salicin
Salmon Oil
Salvianolic acid
Sinomenium acutum
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saponins
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Sulforaphane
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Uncaria
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Products containing Salicin