Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Resveratrol analogs are synthetic or naturally occurring compounds structurally related to resveratrol, a polyphenol found in grapes and other plants. Scientific evidence for their use in supporting or treating rheumatoid arthritis (RA) is emerging, primarily from preclinical studies. In vitro and animal model research suggests that resveratrol and some analogs may exert anti-inflammatory and immunomodulatory effects. These effects are believed to occur through inhibition of pro-inflammatory cytokines (such as TNF-α and IL-6), suppression of NF-κB signaling pathways, and reduction of oxidative stress, all of which are implicated in RA pathogenesis.

However, clinical trials in humans are lacking or very limited. Most published studies involve cell cultures or rodent models of arthritis, which have shown decreased joint inflammation and cartilage destruction after treatment with resveratrol analogs. There are no large-scale, high-quality randomized controlled trials demonstrating efficacy or safety in people with RA. Therefore, while there is scientific rationale and promising preclinical data, the overall evidence supporting the use of resveratrol analogs for RA in humans is weak at present (rated 2/5). Further clinical research is needed to establish their therapeutic potential and safety profile in RA patients.

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