Evidence supporting the use of: Puerarin
For the health condition: Rheumatoid Arthritis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Puerarin is an isoflavone derived from the root of Pueraria lobata (kudzu), a traditional Chinese medicinal plant. Its use in rheumatoid arthritis (RA) is not deeply rooted in historical or traditional medicine for this specific condition, but rather has emerged from scientific investigation into its pharmacological properties. Preclinical studies, primarily in cell cultures and animal models, have shown that puerarin possesses anti-inflammatory and immunomodulatory effects. For instance, research published in peer-reviewed journals has reported that puerarin can inhibit the production of pro-inflammatory cytokines (such as TNF-α and IL-1β), suppress the activation of NF-κB signaling pathways, and reduce synovial hyperplasia—processes relevant to the pathogenesis of RA.

Some studies have demonstrated that puerarin can alleviate joint swelling and tissue damage in collagen-induced arthritis models in rodents, which are commonly used to mimic human RA. These findings suggest a potential therapeutic effect. However, the evidence is limited primarily to preclinical research. There are few, if any, well-designed clinical trials in humans evaluating puerarin's efficacy or safety in the management of RA. As a result, while there is a scientific rationale and some experimental support, the clinical evidence is insufficient, and puerarin should not be considered a proven or standard therapy for RA.

More about Puerarin
More about Rheumatoid Arthritis

Other ingredients used for Rheumatoid Arthritis

adrenal cortex
alfalfa
algal oil
alpha-linolenic acid (ALA)
alpha-pinene
anthocyanins
ashwagandha
astaxanthin
borage oil
celery
coenzyme Q10 (CoQ10)
turmeric
curcumin
d-alpha tocopherol
DHA (docosahexaeonic acid)
diallyl disulfide (DADS)
dong quai root
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
evening primrose oil
fisetin
fish protein
gamma linolenic acid (GLA)
gamma tocopherol
genistein
ginger
green lipped mussel
krill oil
luteolin
methylsulfonylmethane (MSM)
myristoleate
omega-3 fatty acids
phospholipids
resveratrol
rose hips
sardines
slippery elm bark
sulforaphane glucosinolate
Urolithin A
vitamin B6
vitamin C
vitamin D
vitamin D3
watercress
white willow
alpinia galangal
smilax
fumaria parviflora
lingusticum wallichii
amber
teasel
guelder rose
gentiana macrophylla
abies spectabilis
AMP-activated protein kinase (AMPK)
clematis
15,16-Dihydrotanshinone I
Aralia
akebia
Antler
Apigenin
Abrus
Andrographolide
Amentoflavone
Alpha-Lipoic Acid
anthocyanidins
Ampelopsin
Actaea spicata
Acetylsalicylic acid
Arjunic Acid
Apocynin
Arctiin
Astragalin
Boswellic Acid
Baicalein
Bogbean
Boswellia
Black willow
Barbasco
bovine cartilage / glycosaminoglycan
Baicalin
Black Hellebore
Bee venom
Bergenia
Cod Liver Oil
Cortisol
Clerodendrum phlomidis
Cyanidin
Chinese Fleeceflower
Chinese Pond Turtle
Chuchuhuasi
Cetylated Fatty Acids
C-Phycocyanin
Cannabidiol
Carnosic acid
Docosahexaenoic Acid
Dihomo-gamma-linolenic acid
Eicosatetraenoic acid
Eicosapentaenoic Acid
Evening Primrose Oil
Fructoborate
Flemingia philippinensis
Frankincense
Flavanols
Flavones
Ginkgetin

Products containing Puerarin

We currently have no products on Caring Sunshine that contain this ingredient.