Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Perilla oil, derived from the seeds of Perilla frutescens, is rich in alpha-linolenic acid (ALA), an omega-3 fatty acid. Its use in rheumatoid arthritis (RA) is primarily supported by scientific rationale based on the anti-inflammatory properties of omega-3 fatty acids. Several preclinical studies have demonstrated that ALA and its metabolites can reduce the production of pro-inflammatory cytokines and modulate immune responses, which could be beneficial in autoimmune conditions like RA. A small number of animal studies have shown that perilla oil supplementation can reduce inflammatory markers and joint damage in models of arthritis.

However, clinical evidence in humans remains limited. While there are studies supporting the general use of omega-3 fatty acids (such as those from fish oil) in reducing symptoms of RA, direct clinical trials assessing the efficacy of perilla oil specifically in RA patients are scarce. Some small-scale human studies and case reports suggest potential symptomatic improvement, but these are not sufficient for robust clinical recommendations.

Overall, the evidence supporting perilla oil for RA is based on its biochemical properties and limited preclinical data, rather than extensive human clinical trials. Thus, while there is scientific interest, the evidence strength is rated as 2 (weak), indicating potential benefit but insufficient clinical validation.

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