Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Methylsulfonylmethane (MSM) is a sulfur-containing compound found in various foods and sold as a dietary supplement, most often promoted for joint health. The use of MSM for rheumatoid arthritis (RA) is primarily based on its purported anti-inflammatory and antioxidant properties. While MSM is more commonly discussed in the context of osteoarthritis, some small-scale studies and animal models suggest it may help reduce inflammation and pain, which are central to RA symptoms. For example, a few randomized controlled trials have demonstrated that MSM supplementation can decrease subjective pain levels and improve function in people with joint disorders, though most of these studies focus on osteoarthritis rather than RA specifically.

The scientific evidence for MSM’s efficacy in rheumatoid arthritis is limited and not robust. There are no large, high-quality clinical trials directly evaluating MSM in RA patients. Mechanistically, MSM is thought to decrease inflammatory cytokine production and oxidative stress, which could theoretically benefit individuals with RA. However, the bulk of scientific validation comes from laboratory and animal studies, not from comprehensive human trials in the RA population. Therefore, while there is some scientific rationale and preliminary evidence to support the use of MSM for joint health and inflammation, the direct evidence for its use in rheumatoid arthritis is modest at best.

In summary, MSM’s use for rheumatoid arthritis is scientifically based, but the overall evidence is weak (rated 2 out of 5), and more research—especially large, well-designed clinical trials—is necessary to establish its efficacy and safety for this specific condition.

More about methylsulfonylmethane (MSM)
More about Rheumatoid Arthritis

Other ingredients used for Rheumatoid Arthritis

Other health conditions supported by methylsulfonylmethane (MSM)

Products containing methylsulfonylmethane (MSM)

Nature's Sunshine Everflex with Hyaluronic Acid
Nature's Sunshine MSM
Nature's Sunshine Structural System (30 Day Program)