Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Madder (most commonly referring to Rubia cordifolia or Rubia tinctorum) has a history of traditional use in various medical systems, primarily Ayurveda and traditional Chinese medicine. In these traditions, madder is used for its purported anti-inflammatory and blood-purifying properties, which has led to its inclusion in remedies for conditions like rheumatoid arthritis (RA). However, these uses are largely based on empirical tradition rather than rigorous scientific validation. There is limited preclinical research suggesting that extracts of madder may possess anti-inflammatory and immunomodulatory effects, but robust clinical trials in humans with rheumatoid arthritis are lacking. No major medical or rheumatology guidelines recognize madder as an evidence-based treatment for RA. The traditional use is not supported by strong scientific evidence; hence, its rating is low. Adverse effects and potential toxicity (particularly with Rubia tinctorum) have also been noted in some reports. In summary, madder’s use in RA is primarily traditional, with minimal scientific support and no endorsement by mainstream medical authorities.

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