Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Madder (Rubia cordifolia) has a long history of use in traditional medicine systems such as Ayurveda and Traditional Chinese Medicine. In Ayurveda, madder is known as "Manjistha" and is often employed for its purported anti-inflammatory, blood-purifying, and detoxifying properties. It has been used in traditional remedies for conditions involving inflammation and chronic joint diseases, including symptoms associated with Rheumatoid Arthritis (RA). The rationale in these systems is largely based on the plant’s perceived ability to balance the body's humors or doshas, reduce inflammation, and promote tissue healing.

However, scientific evidence supporting the efficacy of madder specifically for RA is limited. Some preclinical studies have demonstrated that compounds in madder (such as mollugin and rubiadin) exhibit anti-inflammatory and immunomodulatory effects in laboratory settings. Yet, there are no robust clinical trials or systematic reviews directly evaluating madder’s effectiveness in treating RA in humans. Most existing studies are either in vitro or animal-based, and do not directly address rheumatoid arthritis but rather general inflammation or immune responses.

In summary, madder’s use for RA is primarily justified by traditional medicine practices rather than strong scientific validation. The evidence rating is 2, as some early-stage scientific research offers biological plausibility, but there is a lack of high-quality clinical data.

More about Madder
More about Rheumatoid Arthritis

Other ingredients used for Rheumatoid Arthritis

Other health conditions supported by Madder

Products containing Madder