Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Hesperetin is a flavonoid primarily found in citrus fruits and has been studied for its anti-inflammatory and antioxidant properties. Scientific interest in hesperetin for rheumatoid arthritis (RA) comes from preclinical studies, mostly in vitro and in animal models. These studies have shown that hesperetin can reduce the production of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6, which play a significant role in the pathogenesis of RA. Additionally, hesperetin has demonstrated the ability to inhibit NF-κB activation, a key transcription factor involved in inflammatory pathways.

For example, a study published in International Immunopharmacology (2019) demonstrated that hesperetin alleviated arthritis symptoms in a mouse model of collagen-induced arthritis by reducing inflammation and joint destruction. Other studies have shown hesperetin's ability to decrease oxidative stress markers and suppress cartilage degradation in vitro.

However, all available evidence is currently limited to laboratory and animal research. There are no clinical trials in humans evaluating hesperetin for RA, so efficacy and safety in patients remain uncertain. While the preclinical data suggest a potential role for hesperetin in modulating the inflammatory processes underlying RA, more rigorous research, including human studies, is needed before hesperetin can be recommended for this purpose.

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