Evidence supporting the use of: Flemingia philippinensis
For the health condition: Rheumatoid Arthritis

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Flemingia philippinensis has been traditionally used in various Asian systems of medicine, particularly within Chinese and Southeast Asian ethnomedicine, for the management of inflammatory disorders, including conditions resembling rheumatoid arthritis (RA). The roots, leaves, and other plant parts are employed in folk remedies to alleviate joint pain, swelling, and stiffness, which are hallmark symptoms of RA. The traditional use is based largely on empirical observations and long-standing herbal practice rather than modern pharmacological validation.

A limited number of in vitro and animal studies on related Flemingia species (such as Flemingia macrophylla) have suggested anti-inflammatory and immunomodulatory activities, but direct, robust scientific evidence specifically addressing Flemingia philippinensis in the context of rheumatoid arthritis is sparse. The bioactive compounds, such as flavonoids and triterpenoids, have been shown in some preclinical studies to inhibit inflammatory mediators, but clinical trials in humans are lacking.

In summary, the use of Flemingia philippinensis for rheumatoid arthritis is supported primarily by traditional knowledge, with partial pharmacological rationale from related species and in vitro studies. However, there is a significant gap in high-quality clinical evidence, and its efficacy and safety for RA in humans remain unproven.

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