Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Fisetin is a plant-derived flavonoid found in various fruits and vegetables, such as strawberries, apples, and onions. Its use for supporting or treating Rheumatoid Arthritis (RA) is based on emerging scientific evidence, primarily from preclinical studies. Research suggests that fisetin exhibits potent anti-inflammatory, antioxidant, and immunomodulatory properties. In animal models of RA, fisetin supplementation has been shown to reduce joint inflammation, inhibit the production of pro-inflammatory cytokines (such as TNF-α and IL-6), and decrease oxidative stress, all of which contribute to the pathogenesis of RA. A few in vitro studies using human cells have demonstrated that fisetin can suppress the activation of pathways implicated in RA, such as NF-κB and MAPK signaling. However, there is currently a lack of robust human clinical trials directly investigating fisetin’s efficacy in RA patients. Most evidence comes from laboratory or animal studies, which, while promising, do not provide a high level of clinical validation. Thus, while fisetin has a scientific rationale for its potential benefits in RA, the current level of evidence is considered preliminary. More well-designed clinical trials in humans are needed before fisetin can be recommended as a standard adjunct therapy for Rheumatoid Arthritis.

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