Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Boswellic acids are bioactive compounds found in the resin of the Boswellia serrata tree, commonly known as Indian frankincense. There is a growing body of scientific evidence supporting the use of Boswellia extracts, standardized to boswellic acids, in the management of inflammatory conditions such as rheumatoid arthritis (RA). Several randomized controlled trials and meta-analyses have indicated that Boswellia extracts can reduce joint pain, swelling, and improve function in patients with RA and other inflammatory arthritides. The proposed mechanisms involve the inhibition of 5-lipoxygenase, an enzyme pivotal in leukotriene synthesis, as well as the suppression of pro-inflammatory cytokines like TNF-α and IL-1β.

Clinical studies, though generally small and of variable quality, consistently demonstrate modest benefits in pain relief and physical function, with a favorable safety profile compared to non-steroidal anti-inflammatory drugs (NSAIDs). Notably, a 2019 systematic review concluded that Boswellia serrata extracts may be effective in reducing pain and improving joint function in patients with osteoarthritis and rheumatoid arthritis, though it called for larger, high-quality trials.

In summary, the use of boswellic acids for rheumatoid arthritis is supported by moderate scientific evidence, justifying its consideration as an adjunctive therapy. However, further large-scale, high-quality trials are necessary to firmly establish its efficacy and optimal dosing in RA management.

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