Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Astragalin is a natural flavonoid compound found in various plants, such as Astragalus membranaceus and Polygonum aviculare. Its use for supporting or treating rheumatoid arthritis (RA) is primarily backed by preclinical (animal and in vitro) scientific studies, rather than traditional medical systems or robust human clinical trials. Several laboratory studies have shown that astragalin has anti-inflammatory and antioxidant properties. For example, research published in International Immunopharmacology (2019) demonstrated that astragalin suppressed inflammatory cytokines and alleviated joint swelling in a mouse model of collagen-induced arthritis, a commonly used animal model for RA. The proposed mechanisms include inhibition of NF-κB and MAPK signaling pathways, which are central to the inflammatory process in RA. However, there are currently no published large-scale human clinical trials evaluating astragalin’s efficacy or safety specifically in RA patients.

Because of this, the evidence supporting the use of astragalin for rheumatoid arthritis is limited to experimental studies in animals and isolated cells, and it has not yet translated into validated clinical recommendations. Therefore, while there is some scientific rationale for its investigation, its use for RA should be considered experimental, and more research—particularly in humans—is needed to determine its effectiveness and safety.

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