Evidence supporting the use of: Andrographolide
For the health condition: Rheumatoid Arthritis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Andrographolide, a diterpene lactone isolated from Andrographis paniculata, has been investigated for its potential in supporting or treating rheumatoid arthritis (RA). Several preclinical studies have demonstrated that andrographolide exhibits anti-inflammatory and immunomodulatory activities relevant to RA pathogenesis. In animal models, andrographolide has been shown to reduce paw swelling, decrease inflammatory cytokine production (such as TNF-α, IL-1β, and IL-6), and suppress joint destruction. Mechanistically, andrographolide appears to inhibit NF-κB signaling and modulate various immune cell functions involved in RA.

Some small-scale clinical trials have evaluated standardized Andrographis paniculata extracts (which contain andrographolide as a main active component) in patients with RA. For example, a double-blind, randomized controlled trial published in 2009 found that patients receiving 100 mg of andrographolide per day for 14 weeks had significant improvements in RA symptoms compared to placebo, including reduced number and severity of swollen joints and improved physician global assessment. However, the overall number of high-quality human studies is limited, and sample sizes have generally been small.

In summary, current evidence for andrographolide in RA is based on a combination of promising preclinical data and a few preliminary clinical studies. While not as robust as established DMARDs or biologics, there is moderate scientific rationale and early clinical support for its use as an adjunct or supportive therapy in RA, warranting further investigation.

More about Andrographolide
More about Rheumatoid Arthritis

Other ingredients used for Rheumatoid Arthritis

adrenal cortex
alfalfa
algal oil
alpha-linolenic acid (ALA)
alpha-pinene
anthocyanins
ashwagandha
astaxanthin
borage oil
celery
coenzyme Q10 (CoQ10)
turmeric
curcumin
d-alpha tocopherol
DHA (docosahexaeonic acid)
diallyl disulfide (DADS)
dong quai root
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
evening primrose oil
fisetin
fish protein
gamma linolenic acid (GLA)
gamma tocopherol
genistein
ginger
green lipped mussel
krill oil
luteolin
methylsulfonylmethane (MSM)
myristoleate
omega-3 fatty acids
phospholipids
resveratrol
rose hips
sardines
slippery elm bark
sulforaphane glucosinolate
Urolithin A
vitamin B6
vitamin C
vitamin D
vitamin D3
watercress
white willow
alpinia galangal
smilax
fumaria parviflora
lingusticum wallichii
amber
teasel
guelder rose
gentiana macrophylla
abies spectabilis
AMP-activated protein kinase (AMPK)
clematis
15,16-Dihydrotanshinone I
Aralia
akebia
Antler
Apigenin
Abrus
Andrographolide
Amentoflavone
Alpha-Lipoic Acid
anthocyanidins
Ampelopsin
Actaea spicata
Acetylsalicylic acid
Arjunic Acid
Apocynin
Arctiin
Astragalin
Boswellic Acid
Baicalein
Bogbean
Boswellia
Black willow
Barbasco
bovine cartilage / glycosaminoglycan
Baicalin
Black Hellebore
Bee venom
Bergenia
Cod Liver Oil
Cortisol
Clerodendrum phlomidis
Cyanidin
Chinese Fleeceflower
Chinese Pond Turtle
Chuchuhuasi
Cetylated Fatty Acids
C-Phycocyanin
Cannabidiol
Carnosic acid
Docosahexaenoic Acid
Dihomo-gamma-linolenic acid
Eicosatetraenoic acid
Eicosapentaenoic Acid
Evening Primrose Oil
Fructoborate
Flemingia philippinensis
Frankincense
Flavanols
Flavones
Ginkgetin

Products containing Andrographolide

We currently have no products on Caring Sunshine that contain this ingredient.