Evidence supporting the use of: Iron
For the health condition: Restless Leg Syndrome

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Iron supplementation for Restless Leg Syndrome (RLS) is supported by scientific evidence. Numerous studies have established a link between iron deficiency and RLS symptoms, with low brain iron levels believed to play a key role in the pathophysiology of the disorder. Clinical guidelines from organizations such as the International Restless Legs Syndrome Study Group (IRLSSG) recommend assessing iron stores (typically via serum ferritin levels) in all patients with RLS. If ferritin levels are below a certain threshold (commonly <50-75 ng/mL), oral or intravenous iron supplementation is often considered, particularly if symptoms are moderate to severe and other causes of RLS have been excluded.

Randomized controlled trials and meta-analyses suggest that iron therapy can reduce the severity of RLS symptoms, especially in those with documented iron deficiency. The beneficial effect is thought to be due to iron's role in dopamine metabolism and neurotransmission within the central nervous system, as iron is a cofactor for tyrosine hydroxylase, the rate-limiting enzyme in dopamine synthesis.

While iron therapy is not universally effective and should not be used indiscriminately (especially in those with normal or high iron stores), there is robust evidence to support its targeted use in iron-deficient RLS patients. Thus, iron is considered a scientifically validated treatment approach for selected individuals with RLS.

More about iron
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Other ingredients used for Restless Leg Syndrome

iron
magnesium
Valerian root
vitamin C
Xanthine
Xanthophyll