Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin E has been investigated for its role in supporting the reproductive system, largely because of its function as a lipid-soluble antioxidant. Early animal studies, particularly in rats, found that Vitamin E deficiency led to infertility and reproductive failure, which initially sparked interest in its potential for human reproductive health. In humans, Vitamin E is present in reproductive tissues, and its antioxidant properties are hypothesized to protect gametes (sperm and ova) from oxidative damage. Some small clinical studies suggest that Vitamin E supplementation may improve sperm motility and reduce oxidative stress in men with infertility, although the evidence is inconsistent and often limited by small sample sizes and methodological weaknesses. For women, research on Vitamin E’s effects on fertility, menstrual health, or pregnancy outcomes is sparse and inconclusive. Major clinical guidelines do not support routine Vitamin E supplementation for reproductive health in otherwise healthy individuals. Overall, while there is some scientific rationale and limited evidence for Vitamin E’s use in male infertility related to oxidative stress, the evidence base remains weak, and more robust, large-scale trials are needed to confirm efficacy for reproductive support in both men and women.

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