Vitamin E, particularly in the form of alpha tocopheryl succinate, has a scientific basis for its use in supporting the reproductive system, though the strength of evidence is moderate. Vitamin E is a fat-soluble antioxidant that helps protect cell membranes from oxidative damage. In the context of reproductive health, Vitamin E has been studied for its role in both male and female fertility. Some clinical studies suggest that Vitamin E supplementation can improve sperm motility and quality in men experiencing infertility, likely by reducing oxidative stress in seminal plasma. In women, Vitamin E has been investigated for its potential to improve endometrial response and decrease oxidative stress, which may be beneficial during assisted reproductive technologies like IVF. However, the results in women are less consistent.

While the antioxidant properties of Vitamin E provide a strong theoretical rationale for its use in reproductive health, and some clinical trials show benefit, the evidence is not universally robust or conclusive. Major health organizations do not routinely recommend Vitamin E supplementation for fertility unless a deficiency is present. Still, its inclusion in fertility-support supplements is backed by a combination of animal studies, small clinical trials, and mechanistic evidence related to its antioxidant function.