Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin E (specifically alpha-tocopherol or its common supplement form, alpha-tocopheryl acetate) has a longstanding association with reproductive health, both in scientific literature and traditional use. Its name itself is derived from "tocopherol," meaning "to carry a pregnancy" in Greek, reflecting early observations that vitamin E is essential for fertility in animals. Scientific validation exists, primarily from animal studies, showing that vitamin E deficiency can lead to reproductive failure, such as fetal resorption and testicular degeneration. In humans, vitamin E acts as an antioxidant, protecting cell membranes—including those in reproductive tissues—from oxidative damage. Some clinical studies suggest that vitamin E supplementation may improve sperm motility and function in men with infertility, particularly when combined with other antioxidants. However, evidence is less robust for its effects on female fertility or other reproductive endpoints in humans, and results from randomized controlled trials are mixed or limited by small sample sizes. Overall, while the biological plausibility and some supportive evidence exist, particularly for male reproductive health, the strength of scientific validation in humans is moderate rather than strong. Thus, vitamin E is used to support the reproductive system based on a combination of mechanistic rationale and limited clinical data, meriting a mid-level evidence rating.

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