Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Vitamin B9, also known as folate or folic acid (in its synthetic form), has strong scientific support for its role in supporting the reproductive system, particularly in women of childbearing age. Folate is crucial for DNA synthesis, cell division, and proper fetal neural tube development. Robust clinical evidence demonstrates that adequate folate intake before conception and during early pregnancy significantly reduces the risk of neural tube defects such as spina bifida and anencephaly. This has led to widespread recommendations for women who are planning pregnancy or are pregnant to supplement with folic acid. Additionally, folate deficiency during pregnancy has been associated with increased risks of miscarriage, preterm birth, and low birth weight. Health organizations such as the CDC, WHO, and ACOG strongly advocate for folic acid supplementation in reproductive-age women as a preventive public health measure. While the evidence is particularly strong for women, some studies also suggest that folate may play a role in male fertility by supporting healthy sperm formation and reducing the risk of chromosomal abnormalities. Overall, the use of folate to support reproductive health is well-grounded in scientific research and clinical guidelines.

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