Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin B9, known as folate or in its synthetic form as folic acid or calcium methyltetrahydrofolate, is well-recognized for its critical role in supporting the reproductive system, particularly during pregnancy. Scientific evidence strongly supports its use in reducing the risk of neural tube defects (NTDs) in developing embryos. Folate is essential for DNA synthesis, repair, and methylation—processes fundamental to cell division and fetal growth. Numerous large-scale studies and meta-analyses have demonstrated that adequate maternal folate status before conception and during early pregnancy significantly decreases the risk of NTDs such as spina bifida and anencephaly. This understanding has led to public health policies recommending or mandating folic acid supplementation and food fortification for women of childbearing age.

Beyond neural tube defect prevention, research suggests folate may play a broader role in fertility and reproductive health. Folate deficiency has been linked to infertility, miscarriage, and poor pregnancy outcomes. Calcium methyltetrahydrofolate, the active and bioavailable form of folate, may be especially beneficial for individuals with genetic polymorphisms (e.g., MTHFR mutation) that impair folic acid metabolism. Thus, scientific validation for the use of Vitamin B9 (particularly in its active forms) in supporting reproductive health—especially for women planning pregnancy or in early gestation—is robust and widely recognized by health authorities globally.

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