Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin B9, particularly in its active form as calcium methylfolate (L-5-methyltetrahydrofolate), has strong scientific support for its role in supporting the reproductive system, especially in women of childbearing age. Folate is essential for DNA synthesis, repair, and methylation, all of which are critical during periods of rapid cell division and growth, such as during pregnancy. Numerous clinical studies have demonstrated that adequate folate intake before and during early pregnancy significantly reduces the risk of neural tube defects (NTDs) in the developing fetus. Because some individuals have genetic variations (such as MTHFR polymorphisms) that reduce their ability to convert folic acid to its active form, supplementation with methylfolate can be particularly effective.

Major health organizations, including the Centers for Disease Control and Prevention (CDC) and the World Health Organization (WHO), recommend folate supplementation for women planning pregnancy. While the strongest evidence pertains to fetal neural development, folate is also vital for overall fertility, proper oocyte (egg) maturation, and may play a role in reducing the risk of certain pregnancy complications. Calcium methylfolate, as a bioavailable form of folate, is thus well-justified and widely used to support reproductive health based on robust scientific validation.

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