Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin B9, particularly in its active form 5-methyltetrahydrofolate (5-MTHF), has well-established scientific support for its role in reproductive health. Folate is crucial for DNA synthesis, repair, and methylation, processes that are especially important during periods of rapid cell division and growth such as pregnancy. Adequate folate levels before and during early pregnancy significantly reduce the risk of neural tube defects (NTDs) in the developing fetus, a finding supported by numerous randomized controlled trials and epidemiological studies. Consequently, public health agencies worldwide recommend folic acid (the synthetic form of B9) supplementation for women of childbearing age and pregnant women.

While folic acid is most commonly used in supplements, 5-MTHF is often preferred for individuals with genetic polymorphisms (e.g., MTHFR mutations) that impair folic acid metabolism. 5-MTHF supplementation ensures optimal folate status in these populations, supporting proper fetal development and reducing reproductive complications. In addition, emerging evidence suggests that adequate folate status may improve fertility in both women and men, possibly by supporting gamete quality and reducing homocysteine levels, though this area warrants further investigation. Overall, the use of Vitamin B9 (as 5-MTHF) for reproductive system support is strongly grounded in scientific evidence, particularly regarding fetal neural development and prevention of birth defects.

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