Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B12 (cobalamin) plays a critical role in DNA synthesis, cell division, and neurological function. While its most well-established uses are for preventing and treating B12 deficiency, anemia, and certain neurological disorders, there is scientific support for its importance in the reproductive system. Adequate B12 levels are necessary for normal gametogenesis (the development of eggs and sperm) and early embryonic development. Deficiency in B12 has been associated with infertility, recurrent pregnancy loss, and neural tube defects in offspring, particularly when accompanied by folate deficiency.

Clinical studies have shown that women with low B12 levels may have a higher risk of infertility or adverse pregnancy outcomes. In men, B12 deficiency can be linked to reduced sperm count and motility. However, while B12 is essential for normal reproductive health, there is limited evidence that B12 supplementation improves fertility or reproductive outcomes in individuals who already have adequate levels. The strongest evidence supports B12 supplementation in deficient individuals or populations at risk of deficiency (e.g., vegetarians, individuals with malabsorption disorders).

In summary, Vitamin B12 is scientifically validated as essential for reproductive system health, particularly through its role in DNA synthesis and cell division. However, direct supplementation benefits are most clearly seen in those with deficiency, and evidence for its use as a fertility enhancer in the general population is moderate.

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