Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin E (specifically mixed tocopherols) has some scientific basis for its role in supporting the reproductive system, but the evidence is moderate and not robust. Historically, Vitamin E was first identified as a "fertility factor" in rats, where deficiency led to fetal resorption and infertility. In humans, Vitamin E is a potent antioxidant, protecting cell membranes—including those of reproductive cells—from oxidative damage. Some clinical studies suggest that Vitamin E supplementation may improve certain markers of male fertility, such as sperm motility and morphology, likely due to its antioxidant properties reducing oxidative stress on sperm cells. There is also emerging evidence that Vitamin E could support endometrial health and improve pregnancy outcomes in women undergoing assisted reproductive treatments, but results are inconsistent and often limited by small study size or methodological issues. Major health authorities do not universally endorse Vitamin E supplementation for reproductive health in the general population, primarily due to the limited and mixed quality of evidence. Therefore, while there is a scientific rationale and some supportive data for Vitamin E’s role in reproductive health, especially related to its antioxidant effects, the evidence is not strong enough to recommend routine supplementation for reproductive support in otherwise healthy individuals.

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