Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Testosterone precursors, also known as prohormones, are substances that the body can convert into testosterone, the primary male sex hormone. Their use to support the reproductive system is rooted in their biological role: testosterone is crucial for the development and maintenance of male reproductive tissues, libido, and secondary sexual characteristics. Scientific studies have demonstrated that, in some cases, supplementing with certain testosterone precursors (such as DHEA or androstenedione) can modestly increase testosterone levels in the body, particularly in individuals with low baseline levels or specific deficiencies. However, the evidence is mixed regarding their efficacy in enhancing reproductive function or fertility in healthy individuals. Regulatory authorities in many countries have raised concerns about the safety and effectiveness of over-the-counter testosterone precursors. Some clinical trials suggest potential benefits in older men or those with hypogonadism, but risks such as hormonal imbalance and adverse cardiovascular effects have also been reported. While there is a physiological rationale and some scientific validation for their use in supporting aspects of reproductive health, the overall quality and consistency of evidence is moderate at best. Thus, the evidence rating is 3 out of 5, reflecting partial scientific support, with significant caveats regarding safety and effectiveness in the general population.

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