Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Ligustilides are a group of phthalide compounds found predominantly in plants such as Angelica sinensis (commonly known as Dong Quai), which has been used for centuries in traditional Chinese medicine (TCM). Historically, extracts containing ligustilide have been used to support women's reproductive health, particularly for alleviating menstrual discomfort, regulating menstruation, and addressing menopausal symptoms. These traditional uses are well-documented in TCM pharmacopeias and ethnobotanical records.

Scientific studies on ligustilide itself are limited, and most available research is preclinical, focusing on animal models or in vitro systems. Some studies have suggested that ligustilide may have antispasmodic and vasodilatory properties, which could theoretically help relieve menstrual cramps and improve uterine blood flow. However, robust clinical trials in humans are lacking. Therefore, while the use of ligustilide-rich herbs for reproductive health is strongly supported by tradition, scientific validation remains preliminary and incomplete. The evidence rating reflects historical continuity and some plausible biological mechanisms, but not rigorous clinical proof.

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