Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Isoflavones are a class of phytoestrogens—plant-derived compounds with estrogen-like activity—found primarily in soybeans and other legumes. Their use to support the reproductive system, particularly in women, has been investigated in a number of scientific studies. Isoflavones, especially genistein and daidzein, have been shown to bind to estrogen receptors, albeit with lower affinity than endogenous estrogen. This has led to research into their potential to alleviate menopausal symptoms such as hot flashes and to support bone health, both of which are linked to reproductive hormone changes.

Clinical trials and meta-analyses suggest that isoflavone supplementation may modestly reduce the frequency and severity of hot flashes in peri- and postmenopausal women. Some studies have also explored isoflavones' potential roles in menstrual regulation and fertility, though the evidence here is less robust. There is also ongoing research into isoflavones' impact on hormonal balance, but results are mixed and sometimes conflicting. In men, evidence for reproductive system benefits is limited and not well established.

Overall, there is moderate scientific support for the use of isoflavones to support aspects of the female reproductive system, particularly in the context of menopause. However, the magnitude of benefit is generally modest, and not all individuals respond equally. More high-quality, long-term studies are warranted to fully elucidate their efficacy and safety.

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