Evidence supporting the use of: Inositol
For the body system: Reproductive System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Inositol, particularly in the form of myo-inositol and D-chiro-inositol, is supported by a significant body of scientific research for its role in supporting the reproductive system, especially in women with polycystic ovary syndrome (PCOS). Multiple randomized controlled trials and meta-analyses have demonstrated that inositol supplementation can improve ovarian function, restore menstrual regularity, and enhance fertility in women with PCOS. The proposed mechanisms include improving insulin sensitivity, reducing hyperandrogenism (high levels of male hormones), and supporting oocyte (egg) quality. Myo-inositol and D-chiro-inositol are both involved in cellular signaling pathways that are crucial for normal reproductive function.

For example, a meta-analysis published in Gynecological Endocrinology (2016) concluded that myo-inositol improved ovulation rates and metabolic parameters in women with PCOS. The evidence for inositol’s benefits in male fertility is weaker but emerging, mainly focused on sperm quality and motility.

Overall, current clinical evidence justifies the use of inositol as an adjunct in supporting reproductive health, particularly for women with PCOS. However, while results are promising, inositol is not a panacea and works best as part of a broader lifestyle and medical management approach. The evidence base is strong enough to warrant its use, especially under medical supervision.

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amino acids
ashwagandha
beta-sitosterol
black cohosh
bovine
bovine liver
broccoli
calcium
chaste tree
Chinese salvia root
choline
coenzyme Q10 (CoQ10)
turmeric
damiana
DHA (docosahexaeonic acid)
DHEA (dehydroepiandrosterone)
DIM (diindolylmethane)
dong quai root
EPA (eicosapentaenoic acid)
evening primrose oil
fennel
fenugreek
fish protein
flaxseed
folate
gamma linolenic acid (GLA)
ginger
ginseng
gokhru
hops
inositol
iodine
iron
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
L-arginine
l-carnitine
lactobacillus crispatus
lactobacillus jensenii
licorice root
lignans
linoleic acid (LA)
maca
magnesium
marine lipid
melatonin
moringa
motherwort
muira puama
omega-3 fatty acids
omega-6 fatty acids
pomegranate
protein
pumpkin
quail egg
raspberry
rehmannia glutinosa
saffron
saw palmetto
selenium
selenium
soybean
spearmint leaf
tongkat ali
tribulus
vitamin A
vitamin B
vitamin D
vitamin E
vitamin E
seaweed
water
wild yam
zinc
sarsaparilla
red clover
suma
squawvine
mugwort
nut grass
anise
punarnava
smilax
chaff flower
Szechuan lovage
yarrow
cistanche
dioscorea
dodder
eucommia
ganoderma
lotus seed
morinda
royal jelly
Equol (proprietary)
guelder rose
trace minerals
anemarrhena asphodeloides
purslane
barrenwort
shepherd's purse
wood betony
hypothalamus
herbal blend (proprietary)
yohimbe
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Aerva lanata
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Agnuside
Ashoka
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Animal protein
Blue Cohosh
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Baliospermum
Black galingale
Beef
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Bugbane
Bulbine natalensis
Black Gram
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Ba Ji Tian
Barbasco
Bee products
Borassus aethiopum
banana
Boerhavia diffusa
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Curculigo orchicides
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Chinese Mountain Ant
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Diosgenin
Date
Eurycomanone
Egg
Euryale seed
Elk antler
Eurycoma Longifolia
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Embelia
Estrogen
Folic Acid
Flueggea suffruticosa
Fo-Ti
Furostanols
formononetin
Fish
Fatty acids
False Unicorn Root
Fadogia agrestis
Ginsenosides
Guava
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Isoflavones
Long Pepper
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Indian Fagonia
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Lipids
Labisia pumila
Macamides
Maral Root
Mezoneuron benthamianum
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Matico
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Miroestrol
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Mandrake
Millettia
Macaenes
Nigella Seed
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Orchid
Osthole
Puerain
Phyllanthus
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Piper chaba
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Protodioscin
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Pedalium
portulaca
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Peptides
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