Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Indole-3-Carbinol (I3C) is a compound naturally found in cruciferous vegetables such as broccoli, cabbage, and Brussels sprouts. Its use in supporting the reproductive system, particularly for women's health, is primarily based on its effects on estrogen metabolism. Scientific research has shown that I3C can modulate the metabolism of estrogen, favoring the production of less potent estrogen metabolites (such as 2-hydroxyestrone) over more potent forms (like 16α-hydroxyestrone), which is thought to be beneficial in conditions influenced by estrogen, such as certain types of estrogen-sensitive breast cancers and cervical dysplasia.

Several clinical studies and laboratory experiments have explored I3C's potential in the management of cervical intraepithelial neoplasia (CIN), a precancerous condition associated with HPV infection. Some randomized controlled trials have demonstrated regression of CIN lesions with I3C supplementation. The compound's role in estrogen metabolism has also led to its investigation for endometriosis and fibroids, though clinical evidence in these areas is less robust.

Overall, the evidence supporting I3C for reproductive system health is moderate, with the best support for use in estrogen-related conditions, especially those involving abnormal cell growth in the cervix. However, more large-scale and long-term studies are needed to firmly establish its efficacy and safety for broader reproductive health applications.

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