Diindolylmethane (DIM) is a compound formed in the body during the digestion of indole-3-carbinol, which is found in cruciferous vegetables such as broccoli and Brussels sprouts. Scientific interest in DIM primarily centers around its effects on estrogen metabolism. Several clinical and preclinical studies have indicated that DIM may promote the formation of beneficial estrogen metabolites, such as 2-hydroxyestrone, over potentially harmful ones like 16-alpha-hydroxyestrone. This modulation of estrogen metabolism has led to research exploring DIM’s potential role in supporting reproductive health, particularly in women.

Clinical trials have investigated DIM’s impact on conditions like cervical dysplasia and symptoms of premenstrual syndrome (PMS), with some positive results, though sample sizes are often small. There is also interest in its potential to support prostate health in men by influencing estrogen and androgen metabolism. While evidence is promising, it is not yet conclusive, and most studies call for larger, well-controlled trials. Overall, scientific validation exists for DIM’s use in supporting the reproductive system, but the strength of evidence is moderate rather than high, meriting a score of 3 out of 5.

References:
- Reed, G. A., et al. (2006). “A Phase I Study of Indole-3-Carbinol in Women: Tolerability and Effects.” Cancer Epidemiology, Biomarkers & Prevention.
- Zeligs, M. A. (1998). “Dietary Indole-3-Carbinol and Diindolylmethane: Safety and Benefits.” Nutrition and Cancer.