Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Daidzein is an isoflavone found primarily in soybeans and other legumes. Its use to support the reproductive system has a basis in scientific evidence, mainly due to its phytoestrogenic activity—meaning it can weakly mimic estrogen in the human body. Several studies have examined daidzein and other soy isoflavones for their effects on reproductive health, particularly in women. Clinical trials have explored their potential benefits for alleviating menopausal symptoms such as hot flashes and night sweats, with some evidence suggesting modest effectiveness. Daidzein may also influence menstrual cycle regulation, though results are mixed and more research is needed. In men, limited studies have assessed possible impacts on testosterone levels and sperm quality, but findings are inconclusive and generally indicate minimal effect at typical dietary intake levels.

The mechanism of action is thought to involve daidzein binding to estrogen receptors, particularly ER-beta, thereby exerting weak estrogen-like effects or acting as an estrogen antagonist depending on endogenous hormone levels. Safety profiles are generally favorable when consumed as part of a normal diet, though high-dose supplementation is not well studied in the long term. Overall, while daidzein's role in reproductive system support is scientifically plausible and partially validated, the strength of evidence is moderate and not universally accepted by all health authorities.

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