Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Probiotics are live microorganisms that, when administered in adequate amounts, confer a health benefit on the host. There is scientific evidence supporting the use of probiotics for certain rectal or lower gastrointestinal tract conditions, primarily related to their role in modulating the gut microbiota and immune responses. Specifically, probiotics have been investigated for the prevention and management of conditions such as ulcerative proctitis (inflammation of the rectum), radiation-induced proctitis, and for reducing symptoms such as diarrhea and inflammation associated with rectal disorders. Meta-analyses and clinical trials suggest that some probiotic strains can help maintain remission in ulcerative colitis, which often involves the rectum, and may reduce the severity of symptoms in radiation proctitis. However, the strength of evidence varies depending on the specific probiotic strain and condition being treated, and not all studies show benefit. The overall evidence base is moderate, with a need for further large-scale, high-quality studies to clarify the most effective strains, doses, and treatment durations. Probiotics are not a primary therapy for rectal diseases but may be considered as adjuncts to standard medical treatments.

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