Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Butyric acid, a short-chain fatty acid produced naturally in the colon by bacterial fermentation of dietary fibers, has scientifically validated benefits for rectal and colonic health. Research indicates that butyric acid is a primary energy source for colonocytes (the cells lining the colon and rectum) and plays a crucial role in maintaining the integrity of the gut mucosal barrier. Several clinical studies have examined the use of butyrate (the salt form of butyric acid) in the management of inflammatory bowel diseases (IBD) such as ulcerative colitis and proctitis. Evidence suggests that butyrate enemas or oral supplementation can reduce inflammation, promote mucosal healing, and alleviate symptoms such as rectal bleeding and pain in patients with distal ulcerative colitis and radiation proctitis. The mechanisms include anti-inflammatory effects, enhancement of mucosal repair, and modulation of local immune responses. While more large-scale and long-term studies are needed, the current body of evidence supports the targeted use of butyric acid in supporting rectal health, especially in specific clinical contexts involving inflammation or mucosal injury. Thus, its use in supporting the rectum is grounded in scientific research, with a moderate to strong level of evidence.

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