Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin E (including mixed tocotrienols) has been investigated for its potential role in managing psoriasis, primarily due to its antioxidant and anti-inflammatory properties. Several small clinical studies and case reports have examined the use of oral or topical vitamin E in psoriasis patients. Some studies suggest that vitamin E can reduce oxidative stress and inflammation, which are believed to contribute to the pathogenesis of psoriasis. For instance, a few trials have reported modest improvements in lesion severity and patient symptoms with vitamin E supplementation, either alone or in combination with other antioxidants. However, these studies often have small sample sizes, short durations, and methodological limitations.

There is some scientific rationale for the use of vitamin E, particularly tocotrienols, since they are more potent antioxidants compared to tocopherols. However, direct clinical evidence specifically examining mixed tocotrienols (as opposed to tocopherols or generic vitamin E) for psoriasis is quite limited. Systematic reviews and meta-analyses generally conclude that the evidence is insufficient to strongly recommend vitamin E, especially in isolation, for psoriasis management. Overall, while there is a scientific basis and some supportive data, the quality and quantity of evidence are modest, and vitamin E should not be considered a primary therapy. It may be used as an adjunct in some cases, but more rigorous research is needed.

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