Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin E (particularly tocopheryl succinate) has some scientific evidence supporting its use in the management of psoriasis, though the evidence is limited and not robust. Several small clinical studies and case reports have explored topical and oral Vitamin E (often in combination with other antioxidants) in patients with psoriasis. Some studies have demonstrated modest improvement in psoriasis severity, attributed primarily to Vitamin E’s antioxidant and anti-inflammatory properties, which may help modulate the oxidative stress and inflammatory pathways involved in psoriasis pathogenesis. For example, a study published in Acta Dermato-Venereologica (1999) found that oral Vitamin E supplementation led to partial improvement of psoriasis symptoms in a subset of patients, though the effect size was moderate and not consistent across all participants. Topical Vitamin E has also been used anecdotally and in small trials, with some reports of reduced erythema and scaling.

However, larger, high-quality randomized controlled trials are lacking, and systematic reviews generally conclude that while Vitamin E may be helpful as an adjunctive therapy, it is not a stand-alone treatment for psoriasis. Its use is sometimes recommended in integrative dermatology settings, but mainstream guidelines do not endorse Vitamin E as a primary therapy. Overall, the scientific evidence is limited and of low-to-moderate quality, justifying a mid-low evidence rating.

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