Evidence supporting the use of: Vitamin E (mixed tocopherols
For the health condition: Psoriasis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin E (mixed tocopherols) has been investigated for its potential role in supporting or treating psoriasis, primarily due to its antioxidant and anti-inflammatory properties. Several small studies and case reports suggest that topical or oral vitamin E may help reduce oxidative stress and inflammation associated with psoriasis, which can contribute to symptom relief. For example, a randomized controlled trial published in the journal Dermatology (2009) showed that a combination of vitamin E and vitamin D3 provided some improvement in mild psoriasis compared to placebo. However, the effect size was modest, and the study population was small. Additionally, some studies have assessed topical vitamin E in combination with other agents, finding slight benefits in skin hydration and reduction of scaling, but not consistently demonstrating marked improvements in psoriasis severity.

Systematic reviews and meta-analyses generally conclude that while vitamin E may have a theoretical benefit due to its antioxidant capacity, the clinical evidence is limited and inconsistent. Major dermatology guidelines do not currently recommend vitamin E as a primary or adjunctive therapy for psoriasis, citing insufficient high-quality evidence. Therefore, while there is some scientific rationale and modest preliminary evidence, the overall support for vitamin E in psoriasis management remains weak (rated 2/5), and more rigorous research is needed to establish its efficacy and safety for this condition.

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Products containing Vitamin E (mixed tocopherols

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