There is some scientific evidence suggesting that Vitamin E, including its beta and delta tocopherol forms, may help support the management of psoriasis, although the evidence is limited and not robust. Vitamin E is a fat-soluble antioxidant with anti-inflammatory properties, which are believed to be beneficial in conditions characterized by oxidative stress and inflammation, such as psoriasis. Small clinical studies and case reports have explored the use of oral and topical Vitamin E in psoriasis patients, often showing modest improvements in symptoms such as scaling, erythema, and plaque thickness. For example, some trials have tested topical Vitamin E either alone or in combination with other agents (like tacalcitol), reporting some degree of improvement in skin lesions compared to placebo. However, the majority of these studies have been small, short in duration, and sometimes lacking rigorous controls.

The majority of the research focuses on alpha-tocopherol, the most common and biologically active form of Vitamin E; there is less direct evidence specifically for beta and delta tocopherols, although these forms share antioxidant properties. Mechanistically, Vitamin E may reduce oxidative stress and modulate immune responses in the skin. Despite these potential benefits, systematic reviews and major dermatological guidelines do not recommend Vitamin E as a primary therapy for psoriasis due to insufficient high-quality evidence. In summary, while there is some scientific rationale and preliminary data, Vitamin E (including beta and delta tocopherols) is only weakly supported by the scientific literature for use in psoriasis.