Evidence supporting the use of: Vitamin E
For the health condition: Psoriasis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin E is an antioxidant that has been investigated for its potential benefits in managing psoriasis, a chronic inflammatory skin disorder. The rationale for its use is primarily based on its antioxidative and anti-inflammatory properties, which could theoretically counteract the oxidative stress and inflammation observed in psoriatic lesions. Several small clinical studies and case reports have explored both topical and oral vitamin E supplementation. Some of these studies suggest modest improvements in psoriasis symptoms, particularly when vitamin E is used in combination with other therapies (such as fish oil or topical corticosteroids). For example, a few trials have demonstrated that topical vitamin E may help reduce scaling and erythema in mild psoriasis. However, the overall scientific evidence remains limited and is not robust. Most studies conducted so far have small sample sizes, lack rigorous controls, or show only marginal effect sizes. Systematic reviews and meta-analyses generally conclude that while vitamin E is well tolerated and may offer some benefit, it cannot be recommended as a primary or stand-alone treatment for psoriasis due to insufficient high-quality evidence. In summary, the use of vitamin E for psoriasis has a plausible scientific rationale and some preliminary supporting evidence, but more large-scale, well-designed clinical trials are needed to establish its efficacy and define its role in psoriasis management.

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