Evidence supporting the use of: Vitamin D3
For the health condition: Psoriasis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin D3 (cholecalciferol), particularly in its active form (calcitriol) or as analogues (e.g., calcipotriol), is scientifically validated for use in the treatment of psoriasis, especially plaque psoriasis. Psoriasis is a chronic, immune-mediated skin condition characterized by hyperproliferation and abnormal differentiation of keratinocytes, as well as inflammation. Vitamin D3 analogues work by regulating the growth and differentiation of skin cells and modulating immune responses. Topical forms of vitamin D3 have been widely used since the 1990s and are recommended in dermatological guidelines worldwide.

Clinical studies have demonstrated that topical vitamin D3 analogues can significantly reduce the severity and extent of psoriatic plaques. They are often used alone or in combination with topical corticosteroids to enhance efficacy and reduce steroid-related side effects. The mechanism of action involves binding to vitamin D receptors in keratinocytes, leading to normalization of cell proliferation and exerting anti-inflammatory effects by modulating T-cell activity and cytokine production.

While oral vitamin D supplementation has also been explored, the strongest evidence supports the use of topical formulations for direct skin effects. Vitamin D3 analogues are considered safe and effective first-line or adjunctive therapies for mild-to-moderate psoriasis. Their safety profile is favorable, with local irritation being the most common side effect. Overall, the use of vitamin D3 in psoriasis is well-supported by scientific evidence and clinical practice guidelines.

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