Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B3, also known as niacin or niacinamide, has some scientific evidence supporting its use in the management of psoriasis, although the evidence is limited and not robust. Niacinamide has anti-inflammatory properties and has been shown in laboratory and some clinical studies to modulate immune function, inhibit neutrophil chemotaxis, and reduce the production of pro-inflammatory cytokines. These mechanisms are relevant to psoriasis, which is characterized by inflammation and immune dysregulation. Small clinical studies and case reports have suggested that topical or oral niacinamide may help reduce the severity of psoriatic lesions and improve skin barrier function. For example, a randomized controlled trial found that topical niacinamide was as effective as topical corticosteroids in reducing scaling and erythema in mild-to-moderate psoriasis. However, large-scale, high-quality clinical trials are lacking, and most guidelines do not recommend niacinamide as a first-line therapy for psoriasis. Traditional use of vitamin B3 for skin conditions is not well-documented, and its current application is based mainly on emerging scientific rationale and limited clinical data. Overall, vitamin B3 may offer benefit as an adjunct in psoriasis management, but more research is needed to establish its efficacy and optimal use.

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