Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin A and its derivatives, known as retinoids, have a well-established role in the management of psoriasis, a chronic inflammatory skin disease. Retinyl palmitate is an ester form of vitamin A and serves as a storage form that can be converted to the active retinol form in the body. The scientific rationale for using vitamin A derivatives in psoriasis is based on their ability to regulate keratinocyte proliferation and differentiation, processes that are dysregulated in psoriatic skin. Topical and systemic retinoids (such as acitretin and tazarotene, which are more potent and specific than retinyl palmitate) are FDA-approved treatments for psoriasis and have demonstrated efficacy in clinical trials.

However, while retinoids as a class are validated for psoriasis treatment, direct evidence supporting the use of retinyl palmitate itself (especially topically or orally at nutritional doses) is limited. Retinyl palmitate is less potent than pharmaceutical retinoids and is primarily used in cosmetic products for general skin health rather than for therapeutic management of psoriasis. Some topical formulations include retinyl palmitate, but clinical studies specifically evaluating its efficacy in psoriasis are sparse. Therefore, while the use of vitamin A derivatives is scientifically validated, the specific use of retinyl palmitate for psoriasis has moderate evidence, largely by extrapolation from better-studied retinoids.

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