Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin A (retinyl acetate) and its derivatives have a scientific basis for their use in the management of psoriasis, primarily through the use of synthetic retinoids rather than direct vitamin A supplementation. Retinoids are compounds structurally related to vitamin A and have been shown to regulate cell growth and differentiation, which is particularly relevant in psoriasis, a disease characterized by hyperproliferation and abnormal differentiation of keratinocytes in the skin.

Oral retinoids such as acitretin (a synthetic analog of vitamin A) are FDA-approved for the treatment of moderate to severe psoriasis, and topical retinoids (like tazarotene) are also used. These therapies have been supported by multiple clinical trials demonstrating their efficacy in reducing psoriatic plaques and improving symptoms. However, direct supplementation with retinyl acetate (the ester form of vitamin A) is not commonly recommended for psoriasis due to the risk of toxicity and lack of evidence supporting its efficacy at safe doses.

Therefore, while the use of vitamin A derivatives is evidence-based and part of modern psoriasis management, the use of basic vitamin A (retinyl acetate) itself is not directly supported by strong clinical evidence for psoriasis treatment. The rating reflects that while there is a scientific rationale and some evidence (especially with related retinoids), retinyl acetate itself is not standard therapy.

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