Evidence supporting the use of: Vitamin A
For the health condition: Psoriasis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin A is scientifically validated for use in the treatment of psoriasis, primarily in the form of its synthetic derivatives known as retinoids. Retinoids, like acitretin and formerly etretinate, are systemic medications derived from vitamin A and are approved for the treatment of moderate to severe psoriasis. Topical retinoids such as tazarotene are also used for milder forms or localized plaques.

The rationale for using vitamin A derivatives in psoriasis centers on their ability to normalize keratinocyte differentiation and proliferation. Psoriasis is characterized by hyperproliferation and abnormal differentiation of skin cells, leading to the formation of thick, scaly plaques. Retinoids modulate gene expression in skin cells, reducing their proliferation and promoting more normal maturation. They also possess anti-inflammatory properties, which can help decrease the inflammation associated with psoriatic lesions.

Multiple randomized controlled trials and clinical guidelines support the efficacy of retinoids in treating psoriasis, particularly when other therapies are ineffective or inappropriate. However, due to potential side effects—including teratogenicity, mucocutaneous symptoms, and liver toxicity—retinoids are generally reserved for carefully selected patients.

In summary, the use of vitamin A derivatives for psoriasis is grounded in robust scientific evidence, with established efficacy and a well-understood mechanism of action, though careful patient selection and monitoring are essential due to the risk of adverse effects.

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