Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Unsaturated fatty acids, particularly omega-3 and omega-6 polyunsaturated fatty acids (PUFAs), have been investigated for their potential role in supporting or treating psoriasis. Scientific interest in these compounds arises from their known anti-inflammatory properties. Psoriasis is a chronic, immune-mediated skin disorder characterized by inflammation and hyperproliferation of keratinocytes. Several clinical trials and meta-analyses have examined the effects of dietary supplementation with unsaturated fatty acids, especially omega-3 fatty acids from fish oil, on psoriasis severity.

Evidence suggests that omega-3 PUFAs may reduce the production of pro-inflammatory cytokines (such as TNF-α and IL-1β) and modulate immune cell function, which are relevant mechanisms in psoriasis pathogenesis. Some randomized controlled trials (RCTs) have reported modest improvements in Psoriasis Area and Severity Index (PASI) scores, scaling, and erythema following omega-3 supplementation. However, results across studies remain mixed: some RCTs show clear benefit, while others report minimal or no effect compared to placebo. Systematic reviews (e.g., Cochrane reviews) generally conclude that while there is a plausible biological rationale and some supportive evidence, the overall quality and consistency of the data is moderate and further robust trials are needed.

In summary, scientific evidence supports a possible benefit of unsaturated fatty acids, particularly omega-3 PUFAs, in psoriasis, but the effect size appears modest, and routine use is not universally endorsed by major dermatological guidelines at this time.

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